protein 1,532 words KG: HSP70 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

HSP70 (Heat Shock Protein 70 / HSPA1A)

🔬 Protein Info
Gene SymbolHSPA1A
Full NameHeat Shock Protein Family A (Hsp70) Member 1A/1B
AliasesHSP70
Chromosome6p21.33 (HSPA1A), 6p21.33 (HSPA1B)
Protein FamilyHeat shock protein 70 family (HSP70 superfamily)
Protein TypeChaperone
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionCytoplasm, nucleus (stress-induced)
Subcellular LocalizationCytoplasm, nucleus (stress-induced)
Molecular Weight70 kDa
Amino Acids640 aa
PathwaysAkt, Apoptosis, Chaperone, Complement, Epithelial-Mesenchymal Transition
UniProt IDP0DMV8
OMIM140100
GeneCardsHSPA1A
Human Protein AtlasHSPA1A
Associated DiseasesALS, Alzheimer, Cancer, Lung Cancer, Ms
Known Drugs/CompoundstRNA, 5S rRNA, Trna, 5S Rrna, Non-Coding Rna, aducanumab
InteractionsTFE3, MAP1LC3A, MLKL, DEPTOR, HMGB1, EGF
KG Connections1134 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.42

Related Analyses (23)

What are the minimal structural requirements for HSP70/HSP90
drug discovery · completed
Do chaperones selectively recognize pathological vs physiolo
protein biochemistry · failed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (6)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
AMBRA1 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

HSP70 interacts_with TFE3
HSP70 interacts_with MAP1LC3A
HSP70 interacts_with MLKL
HSP70 interacts_with DEPTOR
HSP70 interacts_with HMGB1
HSP70 interacts_with EGF
HSP70 interacts_with MLST8
HSP70 interacts_with RICTOR
HSP70 interacts_with MTOR
HSP70 interacts_with PIK3C3