| Gene Symbol | RHOT1 |
| Aliases | Page for RHOT1, Page for RHOT1 Protein |
| Target Class | Protein |
| Function | Calcium-Dependent GTPase Activity: - MIRO1 hydrolyzes GTP to GDP, regulated by calcium binding to EF-hand domains - Calcium influx through NMDA receptors or voltage-gated calcium channels activates MI |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy |
| Subcellular Localization | </th><td>Outer mitochondrial membrane (OMM)</td></tr> |
| Druggability | Low (0.50) |
| Clinical Stage | Phase I |
| Molecular Weight | 71.4 kDa |
| Amino Acids | 618 aa |
| Pathways | mitochondrial homeostasis |
| Ensembl ID | ENSG00000153823 |
| GeneCards | RHOT1 |
| Human Protein Atlas | RHOT1 |
| Associated Diseases | AD, ALI, ALS, Alzheimer, BREAST CANCER |
| Known Drugs/Compounds | Electroacupuncture |
| Interactions | BNIP3L, NDP52, HIF1A, MAP1LC3B, GBA, FUNDC1 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Miro1-Mediated Mitochondrial Trafficking Enhanceme |
| KG Connections | 738 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |