Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PYRAMIDAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PYRAMIDAL |
| Key Genes/Proteins | ACHE, GFAP |
| Related Diseases | NEURODEGENERATION |
Knowledge base pages for this entity
graph TD
PYRAMIDAL["PYRAMIDAL"]
style PYRAMIDAL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
PYRAMIDAL -->|"expressed in"| Cortex((Cortex))
PYRAMIDAL -->|"expressed in"| Spinal_Cord((Spinal Cord))
PYRAMIDAL -->|"expressed in"| Temporal_Lobe((Temporal Lobe))
PYRAMIDAL -->|"expressed in"| Hippocampus((Hippocampus))
PYRAMIDAL -->|"expressed in"| Prefrontal_Cortex((Prefrontal Cortex))
NEURODEGENERATION["NEURODEGENERATION"] -->|"contributes to"| PYRAMIDAL
ASTROCYTE["/ASTROCYTE/"] -->|"expressed in"| PYRAMIDAL
ASTROCYTES["/ASTROCYTES/"] -->|"expressed in"| PYRAMIDAL
MICROGLIA["/MICROGLIA/"] -->|"expressed in"| PYRAMIDAL
CORTEX((CORTEX)) -->|"reduces"| PYRAMIDAL
DNA_DAMAGE["DNA DAMAGE"] -->|"reduces"| PYRAMIDAL
NEURON["/NEURON/"] -->|"reduces"| PYRAMIDAL
NEURONS["/NEURONS/"] -->|"reduces"| PYRAMIDAL| Target | Relation | Type | Str |
|---|---|---|---|
| Temporal Lobe | expressed_in | brain_region | 0.50 |
| Cortex | expressed_in | brain_region | 0.50 |
| Spinal Cord | expressed_in | brain_region | 0.50 |
| Hippocampus | expressed_in | brain_region | 0.50 |
| Prefrontal Cortex | expressed_in | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | contributes_to | disease | 0.65 |
| ASTROCYTE | expressed_in | cell_type | 0.65 |
| ASTROCYTES | expressed_in | cell_type | 0.65 |
| MICROGLIA | expressed_in | cell_type | 0.65 |
| CORTEX | reduces | brain_region | 0.65 |
| NEURON | reduces | cell_type | 0.65 |
| NEURONS | reduces | cell_type | 0.65 |
| NEURON | contributes_to | cell_type | 0.65 |
| NEURON | expressed_in | cell_type | 0.60 |
| NEURONS | expressed_in | cell_type | 0.60 |
| ACHE | protects_against | gene | 0.60 |
| CA1 | protects_against | brain_region | 0.60 |
| GFAP | protects_against | gene | 0.60 |
| NEURON | protects_against | cell_type | 0.60 |
| NEURONS | protects_against | cell_type | 0.60 |
| DEMENTIA | causes | disease | 0.60 |
| FRONTOTEMPORAL | causes | disease | 0.60 |
| CORTEX | contributes_to | brain_region | 0.60 |
| NEURON | impairs | cell_type | 0.60 |
| INTERNEURON | causes | cell_type | 0.60 |
| INTERNEURONS | causes | cell_type | 0.60 |
| NEURON | causes | cell_type | 0.60 |
| NEURONS | causes | cell_type | 0.60 |
| INTERNEURON | expressed_in | cell_type | 0.60 |
| INTERNEURON | regulates | cell_type | 0.60 |
| INTERNEURONS | regulates | cell_type | 0.60 |
| NEURONS | regulates | cell_type | 0.60 |
| CA3 | interacts_with | brain_region | 0.60 |
| HIPPOCAMPUS | interacts_with | brain_region | 0.60 |
| DRD2 | expressed_in | gene | 0.60 |
| ASTROCYTE | inhibits | cell_type | 0.60 |
| ASTROCYTES | inhibits | cell_type | 0.60 |
| CORTEX | co_discussed | entity | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| NEURONS | co_discussed | entity | 0.50 |
| DENDRITIC SPINE | co_discussed | entity | 0.50 |
| GFAP | co_discussed | entity | 0.50 |
| PARIETAL | co_discussed | brain_region | 0.40 |
| ALS | co_discussed | disease | 0.40 |
| FRONTOTEMPORAL | co_discussed | disease | 0.40 |
| MOTOR NEURON | co_discussed | cell_type | 0.40 |
| CA1 | co_discussed | brain_region | 0.40 |
| HIPPOCAMPUS | co_discussed | brain_region | 0.40 |
| ASTROCYTE | co_discussed | cell_type | 0.40 |
| ASTROCYTES | co_discussed | cell_type | 0.40 |
| CA3 | co_discussed | brain_region | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||