concept

STRIATUM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STRIATUM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

526Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

STRIATUM is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, inhibits. Associated with PARKINSON'S DISEASE. Connected to 23 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	STRIATUM
Key Genes/Proteins	SIRT1, GDNF, GAS6
Related Diseases	PARKINSON'S DISEASE, NEUROINFLAMMATION, HUNTINGTON'S DISEASE, INFLAMMATION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    STRIATUM["<b>STRIATUM</b>"]
    STRIATUM -->|"expressed in"| dopaminergic_neurons["dopaminergic neurons"]
    substantia_nigra_pars_compacta["substantia nigra pars compacta"] -->|"interacts"| STRIATUM
    dopamine["dopamine"] -->|"expressed in"| STRIATUM
    D1_medium_spiny_neurons["D1 medium spiny neurons"] -->|"expressed in"| STRIATUM
    COMPLEMENT["COMPLEMENT"] -->|"activates"| STRIATUM
    MICROGLIA["MICROGLIA"] -.protects against.-> STRIATUM
    ATP["ATP"] -->|"expressed in"| STRIATUM
    DRP1["DRP1"] -->|"expressed in"| STRIATUM
    PRKAA1["PRKAA1"] -->|"expressed in"| STRIATUM
    JUN["JUN"] -->|"expressed in"| STRIATUM
    NRF1["NRF1"] -->|"expressed in"| STRIATUM
    OPA1["OPA1"] -->|"expressed in"| STRIATUM

Outgoing (90)

Target	Relation	Type	Str
SUBSTANTIA NIGRA	increases	brain_region	0.65
SUBSTANTIA NIGRA	expressed_in	brain_region	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
HUNTINGTON'S DISEASE	treats	disease	0.65
INFLAMMATION	activates	phenotype	0.65
SUBSTANTIA NIGRA	produces	brain_region	0.65
SIRT1	inhibits	gene	0.65
SIRT1	activates	gene	0.65
GDNF	activates	gene	0.65
SUBSTANTIA NIGRA	treats	brain_region	0.65
GAS6	treats	gene	0.65
TUMOR	associated_with	disease	0.60
NEURODEGENERATION	implicated_in	disease	0.55
SUBSTANTIA NIGRA	depletes	brain_region	0.50
CEREBELLUM	associated_with	concept	0.50
CEREBRAL CORTEX	associated_with	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
CEREBRAL CORTEX	interacts_with	concept	0.50
DOPAMINE	associated_with	concept	0.50
FRONTAL	associated_with	concept	0.50
Proteins	activates	protein	0.50
DOPAMINERGIC NEURONS	activates	concept	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
MTOR SIGNALING	activates	concept	0.50
DOPAMINERGIC NEURONS	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
AADC	inhibits	concept	0.50
NUCLEUS	inhibits	concept	0.50
INTERNEURONS	interacts_with	concept	0.50
INTERNEURONS	associated_with	concept	0.50
SYNCRIP	regulates	concept	0.50
Proteins	regulates	protein	0.50
SYNCRIP	inhibits	concept	0.50
CEREBRAL CORTEX	inhibits	concept	0.50
Proteins	associated_with	protein	0.50
AMYGDALA	associated_with	concept	0.50
DOPAMINE	activates	concept	0.50
PREFRONTAL CORTEX	associated_with	concept	0.50
SNCA	associated_with	gene	0.50
PARKIN	associated_with	gene	0.50
APP	associated_with	gene	0.50
SIRT1	associated_with	gene	0.50
SIRT2	associated_with	gene	0.50
SIRT3	associated_with	gene	0.50
SIRT6	associated_with	gene	0.50
CREB	associated_with	gene	0.50
NLRP3	associated_with	gene	0.50
TLR4	associated_with	gene	0.50
VEGF	associated_with	gene	0.50
CHAT	associated_with	gene	0.50

Incoming (436)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	1.00
CORTEX	expressed_in	brain_region	0.95
MICROGLIA	inhibits	cell_type	0.66
DOPAMINERGIC	reduces	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
AKT	activates	gene	0.65
MTOR	activates	gene	0.65
PI3K	activates	gene	0.65
NEURON	causes	cell_type	0.65
NEURONS	causes	cell_type	0.65
DOPAMINERGIC NEURONS	activates	cell_type	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.65
NEURON	inhibits	cell_type	0.65
HTT	regulates	gene	0.65
GDNF	produces	gene	0.65
NUCLEUS ACCUMBENS	activates	brain_region	0.65
TLR4	inhibits	gene	0.65
TLR4	activates	gene	0.65
TREM2	exacerbates	gene	0.65
TH	causes	gene	0.65
TREM2	activates	gene	0.65
APOPTOSIS	treats	phenotype	0.65
NEURONS	regulates	cell_type	0.65
NEUROINFLAMMATION	activates	phenotype	0.65
GDNF	encodes	gene	0.65
SUBVENTRICULAR ZONE	causes	brain_region	0.65
MICROGLIA	protects_against	cell_type	0.60
ASTROCYTE	causes	cell_type	0.60
CORTEX	targets	brain_region	0.60
FUS	targets	gene	0.60
PARKIN	causes	gene	0.60
DEPRESSION	causes	disease	0.60
GFAP	activates	gene	0.60
NEURODEGENERATION	regulates	process	0.58
NEURONS	depleted_in	cell_type	0.55
DOPAMINE	implicated_in	phenotype	0.55
CEREBELLUM	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
LONG-TERM POTENTIATION	co_discussed	entity	0.50
DOPAMINERGIC	co_discussed	entity	0.50
CEREBRAL CORTEX	expressed_in	brain_region	0.50
ALPHA-SYNUCLEIN	expressed_in	gene	0.50
HIPPOCAMPUS	interacts_with	brain_region	0.50
CORTEX	implicated_in	brain_region	0.50
NEURON	activates	cell_type	0.50
MICROGLIA	activates	cell_type	0.50
DOPAMINERGIC NEURONS	depletes	cell_type	0.50
INTERNEURONS	therapeutic_target	cell_type	0.50
INTERNEURONS	regulates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STRIATUM

Understanding Entity Pages

Summary

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Atypical Parkinsonism

Alpha-Synuclein Pathology

Neurons — Cell Type Hierarchy

neuroinflammation

Multiple System Atrophy

nct07165106

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Growth Factor Therapies

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Oligodendrocytes

Neurotrophin Signaling Pathways in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration