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Home / Wiki / Clinical: Bacillus Subtilis for Parkinson Disease (NCT06487975)

clinical 842 words KG: PD 2026-03-24

kind:clinical-trial section:clinical-trials state:published

Contents

Bacillus Subtilis for Parkinson Disease (NCT06487975)

Knowledge Graph

Related Hypotheses (19)

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming
Score: 0.61 Digital Twin-Guided Metabolic Reprogramming
Score: 0.61 Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S
Score: 0.60 Microbial Inflammasome Priming Prevention
Score: 0.58 PARP1 Inhibition Therapy
Score: 0.58

Smartphone-Detected Motor Variability Correction
Score: 0.56 Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat
Score: 0.52 Ganglioside Rebalancing Therapy
Score: 0.50 Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.49 Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48 APOE Isoform Expression Across Glial Subtypes
Score: 0.48 Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47 Arginine Methylation Enhancement Therapy
Score: 0.46 Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45 Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45 Sphingolipid Metabolism Reprogramming
Score: 0.44 Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44 Piezoelectric Nanochannel BBB Disruption
Score: 0.41 Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.38

Related Analyses (14)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived

Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · completed GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed Gut-Brain Axis Therapeutics for AD
neurodegeneration · completed Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed

Related Experiments (15)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40 SCFA-Mediated Neuroinflammation in Alzheimer's Disease
clinical · proposed · Score: 0.40 Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90 Acteoside treatment in LPS-induced SALI mouse model
validation · proposed · Score: 0.90 RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90 Nrf2 inhibitor ML385 mechanism validation experiment
exploratory · proposed · Score: 0.85 Acteoside effects on RAW264.7 macrophage cells
exploratory · proposed · Score: 0.85 Dexamethasone treatment study in α-synuclein mice
validation · proposed · Score: 0.85 Spatial transcriptomic analysis of multistage ESCC developme
exploratory · proposed · Score: 0.85 TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80 Functional analysis of EFNB1-EPHB4 interaction in EMT
exploratory · proposed · Score: 0.80 Analysis of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in cancer progr
exploratory · proposed · Score: 0.75 LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40 NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (11)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: causes Age-Sensitive Cortical Vulnerability in Parkinson's Dis
mechanism · KG edge: associated_with MCL1 Gene - Myeloid Cell Leukemia 1
gene · KG edge: implicated_in IDH1 Gene - Isocitrate Dehydrogenase 1
gene · KG edge: implicated_in eef1a1
gene · KG edge: implicated_in

DOT1L Gene
gene · KG edge: implicated_in CNTNAP4 Gene
gene · KG edge: associated_with APOB Gene
gene · KG edge: implicated_in ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: implicated_in DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: implicated_in GBA1 (Redirect)
redirect · KG edge: causes

Knowledge Graph (12 edges)

PD causes NEURODEGENERATION

PD causes DOPAMINERGIC_NEURONS

PD causes neurodegeneration

PD contributes_to synucleinopathies

PD associated_with DEPRESSION

PD associated_with T2DM

NEUROINFLAMMATION contributes_to PD

NEUROTROPHINS treats PD

AGE associated_with PD

SNCA causes PD

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