| Gene Symbol | ESR1 |
| Full Name | Estrogen Receptor Alpha |
| Chromosome | 6q25.1 |
| Protein Type | Gene |
| Function | Estrogen Receptor Alpha functions through multiple mechanisms: |
| Primary Expression | brain regions involved in cognition, mood, and neuroprotection, including the hippocampus, [cortex](/brain-regions/corte |
| Pathways | PI3K, MAPK |
| UniProt ID | P03372 |
| NCBI Gene ID | 2099 |
| Ensembl ID | ENSG00000091831 |
| GeneCards | ESR1 |
| Human Protein Atlas | ESR1 |
| Associated Diseases | Aging, Als, Alzheimer, Breast Cancer, Cancer |
| Known Drugs/Compounds | Bisphenol F, Chrysotoxine, DEP, rapamycin |
| Interactions | A2M, ACTB, AKT, AKT1, ALS, AMPK |
| SciDEX Hypotheses | CX3CR1-Negative Trem2-High Microglial Subset Media |
| KG Connections | 845 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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