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gene 1,920 words KG: FUS
Contents

FUS — Fused in Sarcoma

🧬 Gene Info
Gene SymbolFUS
Full NameFused in Sarcoma
Chromosome16p11.2.
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysBlood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt IDSearch UniProt
GeneCardsFUS
Human Protein AtlasFUS
Associated DiseasesAD, Aging, ALI, als
Known Drugs/CompoundsADUCANUMAB, Antisense Oligonucleotide, Rna Oligonucleotides, RNA oligonucleotides
InteractionsACTB, Actin, AD, AGING, ALPHA-SYNUCLEIN, ALS
SciDEX HypothesesASO-Mediated Exon Skipping to Restore FUS-TAZ Chap
FUS Phase Separation Dominance in FTD-TDP: Aberran
Arginine Methylation Loss on FUS RGG Domains Drive (+6 more)
KG Connections1564 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (31)

H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding
Score: 0.74ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis
Score: 0.72Liquid-to-Solid Transition Pathology Reveals Granule Weak Po
Score: 0.71FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensa
Score: 0.68Arginine Methylation Loss on FUS RGG Domains Drives Irrevers
Score: 0.68Small Molecule Modulation of Phase Separation
Score: 0.64RNA-binding protein condensate maturation from reversible ph
Score: 0.63mutant FUS effects split between motor-neuron intrinsic stre
Score: 0.63Optogenetic viral vector delivery via tFUS-mediated blood-br
Score: 0.62FUS Mutations Alter Stress Granule Material Properties to Co
Score: 0.61Cell-state stratification is required to resolve Biophysical
Score: 0.61Cell-state stratification is required to resolve Cell-Autono
Score: 0.61Perturbation-first validation should precede therapeutic cla
Score: 0.61Perturbation-first validation should precede therapeutic cla
Score: 0.61RNA Metabolism and Nucleocytoplasmic Transport Defects
Score: 0.58Closed-Loop Hippocampal TFUS for Gamma Network Target Engage
Score: 0.58Small-Molecule FUS Nuclear Import Correctors Rescue Motor Ne
Score: 0.55Computational Model-Optimized TFUS Parameters for Interneuro
Score: 0.55Low-Intensity tFUS Modulation of EC-DG/EC-CA1 Perforant Path
Score: 0.54Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Co
Score: 0.53
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Knowledge Graph (12 edges)

ACTB interacts_with FUS
OPTN interacts_with FUS
ULK1 interacts_with FUS
SMCR8 interacts_with FUS
CALCOCO2 interacts_with FUS
LC3 interacts_with FUS
BECN1 interacts_with FUS
C9ORF72 interacts_with FUS
NBR1 interacts_with FUS
G3BP1 interacts_with FUS

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