| Gene Symbol | HCN1 |
| Protein Type | Ion Channel |
| Target Class | Ion Channel |
| Function | HCN1 is a cyclic nucleotide-gated channel with unique properties |
| Mechanism of Action | HCN1 encodes a hyperpolarization-activated cyclic nucleotide-gated channel critical for neuronal pacemaking and synaptic integration, with dysregulation linked to hyperexcitability disorders and potential neurodegeneration mechanisms. Specifically, HCN1 channel dysfunction can alter neuronal excitability, synaptic plasticity, and potentially contribute to neuronal death or dysfunction in conditions like epilepsy and neurodegenerative diseases. |
| Subcellular Localization | Dendritic shafts, dendritic spines, axon initial segment |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Pathways | HCN1-Mediated Resonance Frequency Stabilization Th, Scotopic Pathway |
| UniProt ID | A0A0U1RQR7 |
| GeneCards | HCN1 |
| Human Protein Atlas | HCN1 |
| Channel Type | Hyperpolarization-activated cyclic nucleotide-gated channel (HCN1) |
| Primary Structure | Six transmembrane segments (S1-S6) with cyclic nucleotide-binding domain (CNBD) in C-terminus |
| Biophysical Properties | Activated by hyperpolarization, modulated by cAMP, slow kinetics |
| Associated Diseases | Absence Seizures, AD, ALI, Als, Alzheimer's disease |
| Known Drugs/Compounds | ketamine, propofol, Propofol, Zd7288 |
| Interactions | AND, App, BDNF, C1Q, EPILEPSY, Fus |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | HCN1-Mediated Resonance Frequency Stabilization Th HCN1-Selective Blockade Normalizes Thalamic Reboun Ion Channel Stabilization (HCN1/Kv7) |
| KG Connections | 332 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!