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gene 1,494 words KG: SPP1
Contents

SPP1 Gene

🧬 Gene Info
Gene SymbolSecreted Phosphoprotein 1 (Osteopontin)
Chromosome4q21.1
Functionencodes a secreted matricellular glycoprotein that functions as a cytokine, chemokine, and extracellular matrix protein.
Amino Acids314 aa
PathwaysAmyloid, Angiogenesis, Apoptosis, Complement, Immune Response
UniProt IDP08421
NCBI Gene ID6696
Ensembl IDENSG00000118733
OMIM166490
Associated DiseasesAD, aging/AD, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compoundsamyloid-beta oligomers, Bap, BaP, rapamycin, ursolic acid
InteractionsABCA1, Actin, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX HypothesesTemporal SPP1 Inhibition During Critical Windows
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Medi
LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to I (+11 more)
KG Connections476 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (28)

TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects S
Score: 0.81Temporal SPP1 Inhibition During Critical Windows
Score: 0.75SPP1+ DAM as Source of Autoimmunity in Neurodegeneration
Score: 0.66Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift
Score: 0.62Complement Cascade Specificity: Microglial C3aR Antagonism D
Score: 0.62PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In
Score: 0.62LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasom
Score: 0.62Astrocytic SPP1 Modulation Through STAT3-Dependent Transcrip
Score: 0.55Temporal NLRP3 Inhibition During SPP1-Driven Microglial Acti
Score: 0.55Synaptic Vulnerability Window Temporal Targeting: Transient
Score: 0.54CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr
Score: 0.54CD33-Dependent Switch Hypothesis: CD33 Antagonism Redirects
Score: 0.52Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement F
Score: 0.50Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhanc
Score: 0.50TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1
Score: 0.50YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1
Score: 0.49Astrocytic SPP1 Modulation via STAT3-Dependent Transcription
Score: 0.46Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling
Score: 0.45Astrocytic SPP1 Modulation for Neuroinflammatory Resolution
Score: 0.45RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre
Score: 0.44
pg 1/2Next →

Knowledge Graph (12 edges)

SPP1 expressed_in MYELOID_CELLS
SPP1 associated_with CCLM
CTSB activates SPP1
C1QA activates SPP1
SPP1 activates GRN
SPP1 associated_with CD8
SPP1 associated_with CAMK4
SPP1 activates PI3K/Akt/mTOR pathway
SPP1 causes idiopathic pulmonary fibrosis
SPP1 causes NSCLC

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