gene 3,403 words KG: CR1
Contents

CR1 Gene — Complement Component 1q Receptor

🧬 Gene Info
Gene SymbolCR1
Full NameComplement Component 1q Receptor
Chromosome1q32
Protein TypeReceptor
Functionis a gene located on chromosome 1q32.
Primary ExpressionBlood cells (erythrocytes, leukocytes), Brain (microglia, astrocytes), Kidney, Spleen
Molecular Weight250 kDa
Amino Acids1998 aa
Exons38
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Complement, Dysbiosis
UniProt IDP08578
NCBI Gene ID1378
Ensembl IDENSG00000203797
OMIM120600
GeneCardsCR1
Human Protein AtlasCR1
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, CELL SURVIVAL
Known Drugs/CompoundsStem Cell Therapy
InteractionsABCA7, Actin, AD, AGING, ALZHEIMER, ALZHEIMER DISEASE
KG Connections600 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Oligodendrocyte White Matter Vulnerability
Score: 0.65
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
← Prevpg 2/2

Related Analyses (14)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

C1QA associated_with CR1
CLU regulates CR1
C1S associated_with CR1
CLUSTERIN regulates CR1
C1Q regulates CR1
CR1 associated_with CFH
CR1 regulates Amyloid-beta 42
CR1 encodes complement receptor 1
rs6656401 regulates CR1
CR1 associated_with C1QA

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