gene 553 words KG: PILRB 2026-03-24
kind:genesection:genesstate:published
Contents

PILRB Gene

🧬 Gene Info
Gene SymbolPILRB
Chromosome7q22.1.
Protein TypeReceptor
Functionencodes a membrane protein involved in immune cell signaling.
Primary Expressionimmune cells:
Molecular Weight29 kDa
Amino Acids264 aa
Gene TypeProtein Coding
PathwaysPI3K, MAPK pathway
UniProt IDQ9Y5U4
NCBI Gene ID29998
GeneCardsPILRB
Human Protein AtlasPILRB
Gene NamePaired Immunoglobulin-like Type 2 Receptor Beta
DiseaseEvidence Level
Associated DiseasesAlzheimer, Dementia, Ms
InteractionsRGS1, SORL1, CD33, LRRK2, ABCA7, BIN1
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
ZCWPW1 — Zinc Finger CW-Type and PWWP Domain
gene · KG edge: associated_with
CTSH Gene
gene · KG edge: associated_with
CR2 (Complement Receptor Type 2)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PILRB associated_with GBA
PILRB associated_with CR1
PILRB interacts_with RGS1
PILRB interacts_with SORL1
PILRB associated_with ZCWPW1
PILRB regulates RET
PILRB regulates TREM2
PILRB associated_with Alzheimer
PILRB associated_with Dementia
PILRB associated_with Ms