gene 1,566 words KG: EGR4 2026-03-26
kind:genesection:genesstate:published
Contents

EGR4

🧬 Gene Info
Gene SymbolEGR4
AliasesEarly Growth Response 4
Chromosome2p13.3
Protein TypeTranscription Factor
Functionis a zinc finger transcription factor and member of the EGR (Early Growth Response) family of immediate-early genes.
Molecular Weight54 kDa
Amino Acids476 aa
Ensembl IDENSG00000186866
GeneCardsEGR4
Human Protein AtlasEGR4
Associated DiseasesAls, Cancer, Glioblastoma, Ms, Tumor
InteractionsBDNF, FOSB, Bdnf, MICROGLIA, Raf
KG Connections26 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40

See Also (11)

Packard Center for ALS Research
institution · KG edge: associated_with
PTEN Gene
gene · KG edge: associated_with
GLI Gene Family
gene · KG edge: associated_with
FOSB Gene
gene · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

EGR4 associated_with EGFR
EGR4 associated_with CDKN2A
EGR4 associated_with GBM
EGR4 activates BDNF
EGR4 activates FOSB
EGR4 associated_with Cancer
EGR4 associated_with Tumor
EGR4 associated_with Als
EGR4 associated_with Ms
EGR4 associated_with Glioblastoma