gene 924 words KG: ELAVL2 2026-03-24
kind:genesection:genesstate:published
Contents

ELAVL2 Gene

🧬 Gene Info
Gene SymbolELAVL2
Full NameELAV Like RNA Binding Protein 2
Chromosome9p21.3
Protein FamilyELAVL (Embryonic Lethal, Abnormal Vision, Drosophila-like)
FunctionELAVL2 is a member of the ELAVL family (ELAVL1-4) that is expressed specifically in neurons and primarily localizes to the cytoplasm.
Subcellular Localizationof specific mRNAs within neurons, enabling localized protein synthesis at synapses
Molecular Weight~36-39 kDa
PathwaysCholesterol, Lipid Metabolism, Neurogenesis, Translation Fidelity
NCBI Gene ID1993 (NCBI)
GeneCardsELAVL2
Human Protein AtlasELAVL2
Official SymbolELAVL2
ProteinHuB protein
Associated DiseasesALS, Aging, Ftd, Neurodegeneration
InteractionsIGF2BP1, FUS, BRAIN INJURY, METTL3, Proteins, RNA
KG Connections186 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (10)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
CLPP (Caseinolytic Mitochondrial Matrix Peptidase Prote
gene · KG edge: associated_with
CD44 - Cell Surface Glycoprotein
gene · KG edge: associated_with
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ELAVL2 therapeutic_target C1Q
ELAVL2 therapeutic_target MTOR
ELAVL2 therapeutic_target CLPP
ELAVL2 therapeutic_target RAB11
ELAVL2 therapeutic_target STX17
ELAVL2 therapeutic_target RAB5
ELAVL2 therapeutic_target SNAP29
ELAVL2 therapeutic_target IGF2BP1
ELAVL2 therapeutic_target LONP1
ELAVL2 therapeutic_target BDNF