gene 1,597 words KG: IGF2BP1 2026-03-26
kind:genesection:genesstate:published
Contents

IGF2BP1

🧬 Gene Info
Gene SymbolIGF2BP1
Full NameInsulin-Like Growth Factor 2 mRNA-Binding Protein 1
AliasesIMP1, CRD-BP, ZBP1 (Zinc Finger Protein 36-Like 1)
Chromosome17q21.32
Functionis a member of the IMP family of RNA-binding proteins.
Molecular Weight75 kDa
Amino Acids660 aa
Exons17
PathwaysLarval Brain Development, Neural Fate Specification, Neural Progenitor Patterning
UniProt IDQ9Y296
NCBI Gene ID10682
Ensembl IDENSG00000159248
OMIM608288
GeneCardsIGF2BP1
Human Protein AtlasIGF2BP1
Associated DiseasesALS, Aging, Cancer, Ftd, Neurodegeneration
Known Drugs/CompoundsN6-Methyladenosine
InteractionsPTEN, NRF2, G3BP1, ANK2, HNRNPA2B1, COMPLEMENT
KG Connections255 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Phase-Separated Organelle Targeting
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IGF2BP1 therapeutic_target LONP1
IGF2BP1 therapeutic_target BDNF
IGF2BP1 therapeutic_target FUS
IGF2BP1 therapeutic_target C1Q
IGF2BP1 therapeutic_target AKT
IGF2BP1 inhibits PTEN
IGF2BP1 activates NRF2
IGF2BP1 inhibits G3BP1
IGF2BP1 interacts_with ANK2
IGF2BP1 interacts_with PTEN