gene 867 words KG: GRM3 2026-03-21
kind:genesection:genesstate:published
Contents

GRM3 — Glutamate Metabotropic Receptor 3

🧬 Gene Info
Gene SymbolGRM3
Full NameGlutamate Metabotropic Receptor 3
Chromosome7q21.12
Protein FamilyClass C GPCR, mGluR family
Protein TypeReceptor
FunctionmGluR3 is a presynaptic autoreceptor and postsynaptic receptor that
Subcellular Localization**: Presynaptic and postsynaptic membranes
Molecular Weight98 kDa
Amino Acids879 aa
PathwaysMAPK, PI3K, NF-κB
UniProt IDQ14832
NCBI Gene ID2915
Ensembl IDENSG00000138821
OMIM604099
GeneCardsGRM3
Human Protein AtlasGRM3
Associated DiseasesALS, Aging, Alzheimer, Bipolar, Depression
InteractionsGRM4, SYNGR1, GRIN2B, NCAM1, NRG1, RGS4
KG Connections128 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Dementia Australia
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in

Knowledge Graph (12 edges)

GRM3 associated_with DAO
GRM3 associated_with NRG1
GRM3 associated_with GRIN2B
GRM3 associated_with RGS4
GRM3 associated_with NCAM1
GRM3 associated_with DISC1
GRM3 associated_with POLG
GRM3 associated_with FKBP5
GRM3 associated_with SYNGR1
GRM3 associated_with TPH2