gene 1,198 words KG: HNRNPH1 2026-03-26
kind:genesection:genesstate:published
Contents

HNRNPH1 Gene

🧬 Gene Info
Gene SymbolHNRNPH1
Full NameHeterogeneous Nuclear Ribonucleoprotein H1
AliasesHNRPH1, HPRH1, HNRPH
Chromosome5q31.3
FunctionRNA processing, alternative splicing, stress granule formation
Primary Expressionboth neurons and glial cells
Subcellular Localization**Nucleus**: Primary localization; concentrated in splicing speckles
Amino Acids449 aa
Exons10
PathwaysApoptosis, Autophagy, Innate Immunity
UniProt IDP31946
NCBI Gene ID3067
Ensembl IDENSG00000135638
GeneCardsHNRNPH1
Human Protein AtlasHNRNPH1
Associated Diseasesneurodegeneration
InteractionsBRCA2, APOPTOSIS, AUTOPHAGY, PARP1, HNRNPA1, DDX5
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Longevity and Rejuvenation Therapies Landscape
therapeutic · KG edge: regulates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: regulates
SIRT6 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

HNRNPH1 activates BRCA2
HNRNPH1 regulates Aging
HNRNPH1 regulates Neurodegeneration
HNRNPH1 regulates Als
HNRNPH1 regulates Cancer
HNRNPH1 regulates Longevity
HNRNPH1 regulates Ms
HNRNPH1 activates Tumor
HNRNPH1 activates Innate Immunity
HNRNPH1 activates APOPTOSIS