gene 1,468 words KG: DDX5
Contents

DDX5 Gene

🧬 Gene Info
Gene SymbolDDX5
Full NameDEAD-Box Helicase 5 (p68)
AliasesDDX5 (p68) RNA helicase
Chromosome17q21.31
FunctionATP binding: DDX5 binds ATP in motif I
Primary ExpressionHigh in brain (cortex, hippocampus, cerebellum), testis, muscle
Molecular Weight68 kDa
Amino Acids614 aa
PathwaysInnate Immunity
UniProt IDP17844
NCBI Gene ID1652
Ensembl IDENSG00000108654
OMIM180387
GeneCardsDDX5
Human Protein AtlasDDX5
Associated DiseasesAging, Hepatocellular carcinoma, Ms
InteractionsBRCA1, BRCA2, HNRNPA1, HNRNPH1, MCM8, P53
KG Connections45 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
PARP1 Inhibition Therapy
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Nucleolar Stress Response Normalization
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: associated_with
ATM Gene
gene · KG edge: associated_with
ATR Gene
gene · KG edge: regulates
BRCA1 Gene
gene · KG edge: activates
BRCA2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

SIRT6 regulates DDX5
PARP1 activates DDX5
HNRNPA1 activates DDX5
MYC regulates DDX5
DDX5 regulates PIN1
DDX5 activates BRCA1
DDX5 regulates ATR
DDX5 activates HNRNPH1
DDX5 activates BRCA2
PSMB9 associated_with DDX5

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