gene 1,468 words KG: DDX5 2026-03-31
kind:genesection:genesstate:publishedevidence:moderate
Contents

DDX5 Gene

🧬 Gene Info
Gene SymbolDDX5
Full NameDEAD-Box Helicase 5 (p68)
AliasesDDX5 (p68) RNA helicase
Chromosome17q21.31
FunctionATP binding: DDX5 binds ATP in motif I
Primary ExpressionHigh in brain (cortex, hippocampus, cerebellum), testis, muscle
Molecular Weight68 kDa
Amino Acids614 aa
PathwaysInnate Immunity
UniProt IDP17844
NCBI Gene ID1652
Ensembl IDENSG00000108654
OMIM180387
GeneCardsDDX5
Human Protein AtlasDDX5
Associated DiseasesAging, Hepatocellular carcinoma, Ms
InteractionsBRCA1, HNRNPH1, BRCA2, PRP19, MCM8, PARP1
KG Connections45 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: regulates
HNRNPH1 Gene
gene · KG edge: activates
CXCR4 Gene
gene · KG edge: regulates
CXCL12 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

DDX5 regulates PIN1
DDX5 activates BRCA1
DDX5 regulates ATR
DDX5 activates HNRNPH1
DDX5 activates BRCA2
DDX5 associated_with CD8
DDX5 associated_with ATM
DDX5 expressed_in SOD2
DDX5 expressed_in AKT
DDX5 expressed_in VEGFA