gene 652 words KG: HSPA4 2026-03-22
kind:genesection:genesstate:published
Contents

HSPA4 Gene

🧬 Gene Info
Gene SymbolHSPA4
Full NameHeat Shock Protein Family A (Hsp70) Member 4
Chromosome1q22
Protein TypeChaperone
FunctionHSPA4 (also known as Hsp70L1 or Apg-2) is a constitutively expressed Hsp70 family member with multiple cellular functions
Primary ExpressionInducible by stress, constitutively expressed in some tissues
PathwaysNF-κB, MAPK
UniProt IDQ9Y4X5
NCBI Gene ID3309
GeneCardsHSPA4
Human Protein AtlasHSPA4
Protein ClassHsp70 Family
Associated Diseasesneurodegeneration
InteractionsFOXO1, HSP90AA1, PRKACB, PIK3R1, IGF1, CDK1
KG Connections76 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Packard Center for ALS Research
institution · KG edge: activates
IGF1 Gene
gene · KG edge: activates
HSP90B1 Gene
gene · KG edge: activates
HSP90AA1 Gene
gene · KG edge: activates
GNB4 Gene — G Protein Subunit Beta 4
gene · KG edge: activates

Knowledge Graph (12 edges)

HSPA4 regulates FOXP1
HSPA4 regulates DNAJB1
HSPA4 activates FOXO1
HSPA4 activates HSP90AA1
HSPA4 activates PRKACB
HSPA4 activates PIK3R1
HSPA4 activates IGF1
HSPA4 activates CDK1
HSPA4 activates QSOX1
HSPA4 activates LAMB2