| Gene Symbol | MAP3K7 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 7 |
| Chromosome | 6q15 |
| Protein Family | MAP3K family, STE20-like kinases |
| Function | MAP3K7 encodes TAK1 (Transforming Growth Factor Beta-Activated Kinase 1), a serine/threonine kinase that serves as a central mediator of inflammatory, stress-activated, and developmental signaling pat |
| Primary Expression | Ubiquitous (brain, immune, periphery) |
| Molecular Weight | 67 kDa |
| Amino Acids | 606 aa |
| Pathways | TGF-β, NF-κB |
| UniProt ID | [O43318](https://www.uniprot.org/uniprot/O43318) |
| Ensembl ID | ENSG00000171081 |
| OMIM | 602614 |
| GeneCards | MAP3K7 |
| Human Protein Atlas | MAP3K7 |
| IKK complex | TAK1 phosphorylates IKKβ, leading to IκB degradation and NF-κB nuclear translocation |
| Associated Diseases | neurodegeneration |
| Interactions | AMPK, AND, AUTOPHAGY, AXIN, BECN1, CANCER |
| SciDEX Hypotheses | TAK1 Pathway Modulators for Hypothalamic Metabolic |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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