concept

AXIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

AXIN is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 68 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AXIN
Key Genes/Proteins	PSMB1, P62, LATS2, DISC1, TLR2, APC
Related Diseases	Tumor, cancer, Alzheimer, ALS, Carcinoma
Related Pathways	Wnt
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AXIN["AXIN"]
    AXIN -->|"regulates"| cancer["cancer"]
    AXIN -->|"target for"| Alzheimer["Alzheimer"]
    AXIN -->|"activates"| Tumor["Tumor"]
    AXIN -->|"activates"| ALS["ALS"]
    AXIN -->|"target for"| LATS2["LATS2"]
    AXIN -->|"target for"| DISC1["DISC1"]
    AXIN -->|"target for"| TLR2["TLR2"]
    AXIN -->|"target for"| APC["APC"]
    AXIN -->|"target for"| POLE["POLE"]
    AXIN -->|"target for"| Wnt["Wnt"]
    PSMB1["PSMB1"] -->|"regulates"| AXIN
    TCF3["TCF3"] -->|"target for"| AXIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| AXIN
    P62["P62"] -->|"activates"| AXIN

Outgoing (50)

Target	Relation	Type	Str
Tumor	activates	disease	0.75
cancer	regulates	disease	0.70
Alzheimer	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	activates	disease	0.65
LATS2	therapeutic_target	gene	0.60
DISC1	therapeutic_target	gene	0.60
TLR2	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
POLE	therapeutic_target	gene	0.60
Wnt	therapeutic_target	pathway	0.60
Autophagy	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
ATG	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
APC	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GFP	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
CYCLIN D1	associated_with	gene	0.60
STK11	activates	gene	0.60
MIR454	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
TSPAN1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
RAS	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
Actin	associated_with	protein	0.60
RNA	associated_with	gene	0.60
CCND1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
MYC	associated_with	gene	0.60
FAM83A	associated_with	gene	0.60
Raf	activates	protein	0.60
Wnt signaling	participates_in	pathway	0.60
Microrna	activates	pathway	0.50
Pancreatic Cancer	activates	disease	0.50
CYCLIN D1	activates	gene	0.50
RAPAMYCIN	activates	concept	0.50

Incoming (59)

Source	Relation	Type	Str
PSMB1	regulates	gene	0.80
P62	activates	gene	0.70
TCF3	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
ATG	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
APC	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
GFP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
CYCLIN D1	associated_with	gene	0.60
RAS	associated_with	gene	0.60
TFEB	activates	gene	0.60
ROS	activates	gene	0.60
MAP3K7	activates	gene	0.60
PP2A	activates	gene	0.60
KEAP1	activates	gene	0.60
SQSTM1	activates	gene	0.60
TAK1	activates	gene	0.60
AMPK	activates	gene	0.60
NRF2	activates	gene	0.60
NFE2L2	activates	gene	0.60
TFE3	activates	gene	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
FAM83A	associated_with	gene	0.60
AND	activates	gene	0.60
CCND1	associated_with	gene	0.60
TSPAN1	associated_with	gene	0.60
MIR454	associated_with	gene	0.60
APC	inhibits	gene	0.60
GSK3B	activates	gene	0.50
Autophagy	activates	process	0.50
BECN1	activates	gene	0.50
mTOR	activates	entity	0.50
AXIN2	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AXIN

Understanding Entity Pages

Summary

Wiki Pages (20)

GSK-3β in Neurodegeneration

cortisol-tau-pathway

AMPK Signaling Pathway

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

Wnt Signaling in Neurodegeneration

GSK3-beta Protein

GSK3B (Glycogen Synthase Kinase 3 Beta)

GSK-3β

DVL3 — Dishevelled Segment Polarity Protein 3

wnt-beta-catenin-signaling-pathway

FZD8 Protein

CTNNB1 — Catenin Beta 1

DVL2 — Dishevelled Segment Polarity Protein 2

GSK3 Signaling in Parkinson's Disease

Wnt Signaling Modulators for Neurodegeneration

Wnt Signaling in Parkinson's Disease

Beta-Catenin Protein

GSK3-beta Signaling Pathway