gene 790 words KG: MFF 2026-03-24
kind:genesection:genesstate:published
Contents

MFF Gene

🧬 Gene Info
Gene SymbolMFF
Full NameMitochondrial Fission Factor
Chromosome5q31.2
Protein TypeReceptor
FunctionMFF is the major mitochondrial outer membrane receptor for DRP1 (Dynamin 1-like protein), mediating mitochondrial fission through
Gene TypeProtein-coding
PathwaysImmune Response, Mitochondrial Function, Mitophagy, Oxidative Stress, Wnt
UniProt IDQ9NXG2
NCBI Gene ID27245
Ensembl IDENSG00000168955
OMIM614785
GeneCardsMFF
Human Protein AtlasMFF
DiseaseInheritance
EncephalopathyAR
Associated DiseasesALS, Parkinson, Tumor
InteractionsDRP1, MIRO1, MID51, MID49, FIS1, LC3
KG Connections276 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Autophagosome Maturation Checkpoint Control
Score: 0.49
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
DRP1 Gene - Dynamin 1-Like Protein
gene · KG edge: activates
DNM1L Gene
gene · KG edge: regulates
BNIP3L — BCL2 Interacting Protein 3 Like (NIX)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MFF interacts_with DRP1
MFF regulates MAX
MFF regulates TOMM20
MFF interacts_with MIRO1
MFF interacts_with MID51
MFF interacts_with MID49
MFF associated_with DNM1L
MFF activates FIS1
MFF activates LC3
MFF associated_with PRKDC