gene 1,431 words KG: NAGLU 2026-03-22
kind:genesection:genesstate:published
Contents

NAGLU — Alpha-N-Acetylglucosaminidase

🧬 Gene Info
Gene SymbolNAGLU
Full NameAlpha-N-Acetylglucosaminidase
Protein TypeEnzyme
FunctionNAGLU encodes alpha-N-acetylglucosaminidase, a lysosomal enzyme that catalyzes the N-acetylglucosaminide hydrolysis in heparan sulfate glycosaminoglycans.
Molecular Weight73.9 kDa
Amino Acids739 aa
Ensembl IDENSG00000108784
GeneCardsNAGLU
Human Protein AtlasNAGLU
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsPLA2G4A, RBFOX3, RNA, ACTB, ATG12, ATG5
KG Connections20 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Lysosomal Positioning Dynamics Modulation
Score: 0.43
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.40

Related Analyses (5)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

NAGLU activates PLA2G4A
NAGLU activates RBFOX3
NAGLU activates neurodegeneration
NAGLU activates Alzheimer's disease
NAGLU participates_in autophagy pathway
NAGLU expressed_in neurons
NAGLU activates RNA
NAGLU activates traumatic brain injury
ACTB activates NAGLU
ATG12 activates NAGLU