gene 1,208 words KG: CTSL
Contents

CTSL Gene

🧬 Gene Info
Gene SymbolCTSL
Full NameCathepsin L
Chromosome9q21.33
Protein TypeProtease
Functionencodes a lysosomal cysteine protease that plays crucial roles in protein degradation, antigen processing, and extracellular matrix remodeling.
Primary ExpressionUbiquitous; highest in liver
Amino Acids333 aa
Exons8
PathwaysAutophagy
UniProt IDP07711
NCBI Gene ID1517
Ensembl IDENSG00000135047
OMIM116830
GeneCardsCTSL
Human Protein AtlasCTSL
Associated DiseasesNeurodegeneration, Parkinson
InteractionsCTSS, JAK2, STAT3, APP, CX3CL1, CX3CR1
KG Connections139 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49
VCP-Mediated Autophagy Enhancement
Score: 0.41
APOE-Dependent Autophagy Restoration
Score: 0.61
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (6)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

CTSL therapeutic_target FOXO3
CTSL regulates PIK3R1
CTSL regulates BECN1
CTSL regulates STAT3
CTSL regulates CTSB
CTSL regulates HIF1A
CTSL therapeutic_target FOXO1
CTSL regulates PIK3C3
CTSL therapeutic_target EIF2AK2
CTSL activates CTSS