gene 1,181 words KG: P2X7 2026-03-24
kind:genesection:genesstate:published
Contents

Purinergic Receptor P2X 7 (P2X7)

🧬 Gene Info
Gene SymbolP2X7
Full NameP2X Purinoceptor 7
Chromosome12q24.31.
Protein TypeChannel
FunctionIn the healthy brain, P2X7 serves several important physiological roles:
Molecular Weight68.5 kDa
Amino Acids595 aa
Exons17
PathwaysAmyloid, Apoptosis, Er Stress, Inflammasome, Microrna
Ensembl IDENSG00000088038
GeneCardsP2X7
Human Protein AtlasP2X7
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Autoimmune, Cancer
InteractionsP2RX7, P2RX4, SRC, CX3CR1, AKT, VDAC1
KG Connections384 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Purinergic Signaling Polarization Control
Score: 0.55
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (5)

P2rx7 congenic mouse model insulin tolerance testing
validation · proposed · Score: 0.90
P2rx7 congenic mouse model glucose tolerance testing
validation · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
ASC (PYCARD)
gene · KG edge: activates

Knowledge Graph (12 edges)

P2X7 associated_with P2RX7
P2X7 associated_with P2RX4
P2X7 activates P2RX7
P2X7 activates P2RX4
P2X7 activates SRC
P2X7 contributes_to NLRP3
P2X7 activates CX3CR1
P2X7 activates AKT
P2X7 interacts_with P2RX7
P2X7 activates VDAC1