Contents

PDHA1

🧬 Gene Info

Gene Symbol	PDHA1
Full Name	Pyruvate Dehydrogenase E1 Alpha 1
Chromosome	19q13.42
Protein Family	Pyruvate dehydrogenase complex (PDC) family
Function	is a heterotetramer composed of two α subunits (PDHA1 or PDHA2) and two β subunits (PDHB), forming the catalytic core of the larger pyruvate dehydrogenase complex[@hi2006].
Primary Expression	Ubiquitous (brain, heart, muscle, liver)
Molecular Weight	43 kDa
Amino Acids	390 aa
Exons	11
Pathways	NF-κB
UniProt ID	P21987
NCBI Gene ID	5165
Ensembl ID	ENSG00000131828
GeneCards	PDHA1
Human Protein Atlas	PDHA1
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Leigh Syndrome
Interactions	AND, Bdnf, BDNF, CAT, COX4I1, CYCS
KG Connections	64 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph