| Gene Symbol | PDHA1 |
| Full Name | Pyruvate Dehydrogenase E1 Alpha 1 |
| Chromosome | 19q13.42 |
| Protein Family | Pyruvate dehydrogenase complex (PDC) family |
| Function | is a heterotetramer composed of two α subunits (PDHA1 or PDHA2) and two β subunits (PDHB), forming the catalytic core of the larger pyruvate dehydrogenase complex[@hi2006]. |
| Primary Expression | Ubiquitous (brain, heart, muscle, liver) |
| Molecular Weight | 43 kDa |
| Amino Acids | 390 aa |
| Exons | 11 |
| Pathways | NF-κB |
| UniProt ID | P21987 |
| NCBI Gene ID | 5165 |
| Ensembl ID | ENSG00000131828 |
| GeneCards | PDHA1 |
| Human Protein Atlas | PDHA1 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Leigh Syndrome |
| Interactions | Bdnf, BDNF, CAT, COX4I1, CYCS, GENES |
| SciDEX Hypotheses | Primed microglia occupy a hybrid high-glycolysis a |
| KG Connections | 63 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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