gene 890 words KG: PPP1R15A
Contents

PPP1R15A Gene

🧬 Gene Info
Gene SymbolPPP1R15A
AliasesGADD34
Chromosome19q13
Protein TypeGene
Functionencodes a stress-inducible scaffold that recruits catalytic PP1 phosphatase to phospho-eIF2alpha substrates.
PathwaysBlood-Brain Barrier, Er Stress
GeneCardsPPP1R15A
Human Protein AtlasPPP1R15A
Associated Diseasesneurodegeneration
InteractionsAND, ATF4, CLDN5, CXCL1, CXCL2, CYTOKINES
KG Connections63 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

IL6 (Redirect)
redirect · KG edge: activates
ATF4 Gene
gene · KG edge: activates
CLDN5 — Claudin-5
gene · KG edge: activates
CXCL1
gene · KG edge: activates
CXCL2 — C-X-C Motif Chemokine Ligand 2
gene · KG edge: activates

Knowledge Graph (12 edges)

CXCL2 therapeutic_target PPP1R15A
IL6 therapeutic_target PPP1R15A
ATF4 activates PPP1R15A
PPP1R15A therapeutic_target IL12B
PPP1R15A activates XBP1
PPP1R15A therapeutic_target CXCL1
PPP1R15A activates DDIT3
PPP1R15A therapeutic_target CLDN5
PPP1R15A activates HSPA5
PPP1R15A therapeutic_target OCLN

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