| Gene Symbol | IRE1 |
| Function | Inositol-requiring enzyme 1 (IRE1) is the most evolutionarily conserved sensor of the unfolded protein response (UPR) |
| Molecular Weight | 110 kDa |
| Pathways | Endoplasmic Reticulum Stress |
| GeneCards | IRE1 |
| Human Protein Atlas | IRE1 |
| Interactor | Relationship |
| [BiP/GRP78](/proteins/grp78) | ER luminal chaperone |
| [XBP1](/proteins/xbp1-protein) | Splicing substrate |
| [PERK](/proteins/eif2ak3-protein) | Parallel UPR sensor |
| [ATF6](/proteins/atf6-protein) | Parallel UPR sensor |
| TRAF2 | Kinase adaptor |
| Associated Diseases | Cardiovascular, Diabetes, Neurodegeneration |
| Known Drugs/Compounds | Dolutegravir, DTG, rapamycin |
| Interactions | IL6, CXCL1, ATF4, PPP1R15A, IL23A, CLDN5 |
| KG Connections | 225 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |