gene 1,824 words KG: PRNP 2026-03-29
kind:genesection:genesstate:publishedtopic:prion-diseasetopic:alzheimers
Contents

PRNP — Prion Protein

🧬 Gene Info
Gene SymbolPRNP
Full NamePrion Protein (Kanno Blood Group)
Chromosome20p13
Functionis a gene located on chromosome 20p13 that encodes the major prion protein (PrP), a glycosylphosphatidylinositol (GPI)-anchored glycoprotein of 253 amino acids[@genetic2003].
Primary ExpressionCerebral cortex, Cerebellum, Hippocampus, Thalamus, Basal ganglia, Brainstem
Amino Acids253 aa
PathwaysAmyloid
UniProt IDP04156
NCBI Gene ID5621
Ensembl IDENSG00000171867
OMIM176640
GeneCardsPRNP
Human Protein AtlasPRNP
Associated DiseasesALS, Aging, Alzheimer, Creutzfeldt-Jakob, Prion Disease
InteractionsIL1A, SORL1, BACE1, SNCA, TH, Prion
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.63
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (8)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (2)

Pre-Symptomatic Detection and Intervention Timing in Genetic
validation · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability in CJD
clinical · proposed · Score: 0.40

See Also (11)

Alzheimer Indonesia
institution · KG edge: associated_with
PLAU Gene (Urokinase)
gene · KG edge: associated_with
MAPT - Microtubule-Associated Protein Tau
scidex_docs · KG edge: associated_with
IL1A — Interleukin 1 Alpha
gene · KG edge: associated_with
IL10 — Interleukin 10
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PRNP associated_with Creutzfeldt-Jakob
PRNP associated_with IDE
PRNP associated_with TGFB1
PRNP associated_with BACE1
PRNP associated_with HSPG2
PRNP associated_with IL10
PRNP associated_with ACE
PRNP associated_with SORL1
PRNP associated_with BDNF
PRNP associated_with MAPT

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