gene 605 words KG: RGS1 2026-03-21
kind:genesection:genesstate:published
Contents

RGS1 — Regulator of G Protein Signaling 1

🧬 Gene Info
Gene SymbolRGS1
Full NameRegulator of G Protein Signaling 1
Chromosome1q31.2
FunctionThis activity rapidly terminates GPCR signaling by promoting Gα-GTP reassociation with Gβγ dimers, effectively serving as a molecular timer for GPCR signal transduction.
Primary ExpressionLymphoid tissues, Spleen, Lymph nodes, Blood leukocytes
Amino Acids206 aa
UniProt IDQ08169
NCBI Gene ID5996
Ensembl IDENSG00000190125
OMIM607070
GeneCardsRGS1
Human Protein AtlasRGS1
InteractionsATF3, VIM, RAB27A, COL4A1, ZFP36, HSPB1
KG Connections49 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Purinergic Signaling Polarization Control
Score: 0.55
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41

Related Analyses (8)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: inhibits
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: activates
VIM Gene
gene · KG edge: activates
RAB27A Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

RGS1 activates ATF3
RGS1 activates VIM
RGS1 inhibits RAB27A
RGS1 inhibits COL4A1
RGS1 activates ZFP36
RGS1 activates HSPB1
RGS1 activates CH25H
RGS1 activates Inflammation
RGS1 activates Stroke
RGS1 activates Als