gene 863 words KG: S100A8 2026-03-21
kind:genesection:genesstate:published
Contents

S100A8 - S100 Calcium Binding Protein A8

🧬 Gene Info
Gene SymbolS100A8
Full NameS100 Calcium Binding Protein A8
Chromosome1q21.3
Protein FamilyS100 calcium-binding protein family
FunctionS100A8 and the S100A8/A9 complex (calprotectin) have several critical functions
Primary Expressionspecific cell types and pathological conditions
Molecular Weight10.8 kDa
Amino Acids93 aa
Exons3
PathwaysNF-κB, MAPK signaling
GeneCardsS100A8
Human Protein AtlasS100A8
Associated DiseasesAlzheimer, Cancer, Heart Failure, Lupus, Ms, Sepsis
Known Drugs/CompoundsGW201
InteractionsCD47, MMP9, TNF, TLR4, MMP2, S100A9
KG Connections303 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (10)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
CD68 Gene
gene · KG edge: expressed_in
CD47 Gene
gene · KG edge: inhibits
CASP1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

S100A8 inhibits CD47
S100A8 expressed_in GFAP
S100A8 inhibits MMP9
S100A8 inhibits TNF
S100A8 inhibits TLR4
S100A8 expressed_in CD68
S100A8 inhibits MMP2
S100A8 regulates TLR4
S100A8 regulates FGF8
S100A8 regulates CSF2