gene 562 words KG: SESN1 2026-03-24
kind:genesection:genesstate:published
Contents

SESN1 Gene

🧬 Gene Info
Gene SymbolSESN1
Chromosome6q21<br>
FunctionSESN1 performs several critical cellular functions
Molecular Weight56 kDa
PathwaysmTOR, mtor, AMPK, AMPK signaling
UniProt IDQ9Y7X8
NCBI Gene ID27145
Ensembl IDENSG00000080589
GeneCardsSESN1
Human Protein AtlasSESN1
AMPK ActivationActivates AMPK to promote metabolic adaptation
Antioxidant DefenseInduces expression of antioxidant enzymes via NRF2
DNA Damage ResponseInduced by p53 in response to DNA damage
ProteostasisHelps maintain protein quality control
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Metabolic Syndrome, Cancer
InteractionsCDKN1A, NDRG2, DUSP1, PPP5C, PRKAA2, CCND1
KG Connections72 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: regulates
PPP5C — Protein Phosphatase 5 Catalytic Subunit
gene · KG edge: regulates
PDK4 (3-Phosphoinositide-Dependent Protein Kinase-4)
gene · KG edge: regulates
NPY1R Gene
gene · KG edge: regulates
NFKBIA Gene (NFKB Inhibitor Alpha)
gene · KG edge: regulates

Knowledge Graph (12 edges)

SESN1 regulates STING1
SESN1 regulates CGAS
SESN1 regulates IRF1
SESN1 regulates NDRG2
SESN1 regulates SOX9
SESN1 regulates MYH2
SESN1 regulates VPS37B
SESN1 regulates NFKBIA
SESN1 regulates CALM2
SESN1 regulates NPY1R