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gene 2,913 words KG: SLC22A1
Contents

SLC22A1 Gene

🧬 Gene Info
Gene SymbolSLC22A1
Full NameSolute Carrier Family 22 Member 1 (OCT1)
Chromosome11q13.4
Functionencodes a polytopic membrane protein with 12 predicted transmembrane domains, characteristic of the major facilitator superfamily (MFS).
Molecular Weight61 kDa
Amino Acids554 aa
Exons12
UniProt IDO15245
NCBI Gene ID6579
Ensembl IDENSG00000175084
OMIM607607
GeneCardsSLC22A1
Human Protein AtlasSLC22A1
Associated Diseasesneurodegeneration
InteractionsABCB1, CHAT, CHRNA7, CYP2D6, CYP3A4, DEMENTIA
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (10)

s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40ApoE4 Function in Alzheimer's Disease
validation · proposed · Score: 0.40Biomarker-Guided Sequential Therapy Selection in Alzheimer's
clinical · proposed · Score: 0.40

See Also (15)

LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 10 hypothesesremternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypothesesUPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypothesesBEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 9 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

PPAR transports SLC22A1
APOE transports SLC22A1
ABCB1 transports SLC22A1
CHAT transports SLC22A1
ACE transports SLC22A1
BCHE transports SLC22A1
CHRNA7 transports SLC22A1
CYP2D6 transports SLC22A1
SLC22A1 transports CYP3A4
acetylcholine interacts_with SLC22A1

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