gene

CYP2D6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP2D6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

265Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CYP2D6 encodes a key drug-metabolizing enzyme with over 100 known alleles affecting drug response. Strongly implicated in Parkinson's disease risk through metabolism of neurotoxins and neuroprotective compounds.

View on Wiki →

🧬 Gene Info

Gene Symbol	CYP2D6
Full Name	Cytochrome P450 2D6
Protein Type	Enzyme
Function	encodes a crucial phase I drug-metabolizing enzyme that plays a pivotal role in the metabolism of approximately 25% of all clinically used drugs.
Molecular Weight	56 kDa
Amino Acids	497 aa
Pathways	Oxidative Stress
Ensembl ID	ENSG00000100168
GeneCards	CYP2D6
Human Protein Atlas	CYP2D6
Catalytic reaction type	Hydroxylation, O-dealkylation, N-dealkylation
Cofactor requirement	NADPH-cytochrome P450 reductase
Substrate preference	Planar aromatic compounds with a nitrogen-containing basic group
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Anxiety
Known Drugs/Compounds	antidepressant drugs
Interactions	JUN, CHAT, SLC22A1, CHRNA7, PPAR, CYP3A4
KG Connections	265 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Rotigotine and Rivastigmine Combination Therapy for Alzheimer's Disease (NCT06702124)

clinical · 3657 words

→

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

clinical · 3402 words

→

Riluzole ALS Trials

clinical · 3263 words

→

Pathway Diagram

graph TD
    CYP2D6["CYP2D6"]
    CYP2D6 -->|"target for"| Dementia["Dementia"]
    CYP2D6 -->|"activates"| Parkinson["Parkinson"]
    CYP2D6 -->|"activates"| Als["Als"]
    CYP2D6 -->|"target for"| Ms["Ms"]
    CYP2D6 -->|"activates"| ALS["ALS"]
    CYP2D6 -->|"target for"| Epigenetic["Epigenetic"]
    JUN["JUN"] -->|"activates"| CYP2D6
    GENES["GENES"] -->|"target for"| CYP2D6
    DNA["DNA"] -->|"activates"| CYP2D6
    PER["PER"] -->|"interacts"| CYP2D6
    GPNMB["GPNMB"] -->|"transports"| CYP2D6
    NUCKS1["NUCKS1"] -->|"transports"| CYP2D6

Outgoing (163)

Target	Relation	Type	Str
antidepressant drugs	modulates	drug	0.85
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Dementia	associated_with	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Cancer	causes	disease	0.65
Fibrosis	causes	disease	0.65
Als	causes	disease	0.65
Autoimmune	regulates	disease	0.65
Fibrosis	activates	disease	0.65
Hepatitis	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Vascular Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60

Incoming (102)

Source	Relation	Type	Str
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
JUN	activates	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
DES	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60
SLC6A2	transports	gene	0.60
XRCC1	causes	gene	0.60
TP53	causes	gene	0.60
SLC6A4	associated_with	gene	0.60
SLC6A3	transports	gene	0.60
APOE	transports	gene	0.60
LRRK2	transports	gene	0.60
SLC6A4	transports	gene	0.60
GCH1	transports	gene	0.60
ABCB1	transports	gene	0.60
DRD2	transports	gene	0.60
SNCA	transports	gene	0.60
CHAT	therapeutic_target	gene	0.60
CYP3A4	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
PPAR	transports	gene	0.60
CHAT	transports	gene	0.60
ACE	transports	gene	0.60
BCHE	transports	gene	0.60
CHRNA7	transports	gene	0.60
CHRNA7	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CYP2D6

Understanding Entity Pages

Summary

Wiki Pages (21)

CYP2D6 — Cytochrome P450 2D6

Curcumin for Neurodegeneration

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

Rotigotine and Rivastigmine Combination Therapy for Alzheimer's Disease (NCT06702124)

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

Riluzole ALS Trials

LY03020 - Luye Pharma Phase 1 Trial

karxt-nct07011745

proteostasis-triad-pulses

rivastigmine

Progressive Supranuclear Palsy (PSP) Treatment Guide

donepezil

Otsuka Pharmaceutical

KarXT (Xanomeline/Trospium) - Phase 3 for Alzheimer's Disease Psychosis

Section 216: Advanced Pharmacogenomics for CBS/PSP

nct05980949

Donepezil

pharmacogenomics-cbs-psp

Section 160: Pharmacogenomics and Personalized Medicine in CBS/PSP