| Gene Symbol | SMO |
| Full Name | Smoothened, Frizzled Class Receptor |
| Chromosome | 7q32.1 |
| Protein Type | Receptor |
| Function | encodes a 793 amino acid class F G protein-coupled receptor (GPCR) that serves as the essential signal transducer of the Hedgehog (Hh) signaling pathway. |
| Primary Expression | neural progenitor cells of the ventricular zone, the external granular layer of the cerebellum, and the subventricular zone (SVZ) |
| Amino Acids | 793 aa |
| Exons | 12 |
| Pathways | Apoptosis, Hedgehog |
| Ensembl ID | ENSG00000128602 |
| GeneCards | SMO |
| Human Protein Atlas | SMO |
| Gαi coupling | SMO activates heterotrimeric Gi proteins, reducing cAMP and modulating PKA activity independently of GLI |
| Ca²⁺ signaling | SMO-Gαi coupling triggers phospholipase C (PLC) activation and inositol trisphosphate (IP3)-dependent Ca²⁺ release from the ER |
| Small GTPases | SMO activates RhoA and Rac1 to regulate cytoskeletal dynamics, growth cone guidance, and axonal pathfinding |
| Associated Diseases | ALS, AMELOBLASTOMA, Cancer, Carcinoma, Medulloblastoma |
| Interactions | GLI2, GLI1, BCL2, SHH, APOPTOSIS, CANCER |
| KG Connections | 63 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |