GLI1

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive guide to GLI1 transcription factor in Hedgehog signaling and its role in neurodegeneration

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graph TD
    GLI1["<b>GLI1</b>"]
    AUTOPHAGY(["AUTOPHAGY"])
    GLI1 -->|"regulates"| AUTOPHAGY
    Ms{"Ms"}
    GLI1 -->|"activates"| Ms
    GLI1 -->|"regulates"| Ms
    Als{"Als"}
    GLI1 -->|"regulates"| Als
    ALS{"ALS"}
    GLI1 -->|"regulates"| ALS
    BCL2["BCL2"]
    GLI1 -->|"associated with"| BCL2
    Hedgehog(["Hedgehog"])
    GLI1 -->|"activates"| Hedgehog
    Autophagy(["Autophagy"])
    GLI1 -->|"activates"| Autophagy
    PDGFRB["PDGFRB"]
    GLI1 -->|"regulates"| PDGFRB
    PDGFRA["PDGFRA"]
    GLI1 -->|"regulates"| PDGFRA
    ATG["ATG"]
    GLI1 -->|"activates"| ATG
    ATG7["ATG7"]
    GLI1 -->|"activates"| ATG7
    BNIP3["BNIP3"]
    BNIP3 -->|"activates"| GLI1
    BECN1["BECN1"]
    BECN1 -->|"associated with"| GLI1
    ATG7 -->|"activates"| GLI1
    ATG -->|"activates"| GLI1
    BCL2 -->|"associated with"| GLI1
    ATG12["ATG12"]
    ATG12 -->|"expressed in"| GLI1
    PDGFRA -->|"regulates"| GLI1
    THBS2["THBS2"]
    THBS2 -->|"regulates"| GLI1
    ACETYL_COA["ACETYL-COA"]
    ACETYL_COA -->|"activates"| GLI1
    AUTOPHAGY -->|"activates"| GLI1
    AND["AND"]
    AND -->|"activates"| GLI1
    style GLI1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0