Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GLI2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Cancer, Colorectal Cancer, Tumor. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | GLI2 |
| Full Name | GLI Family Zinc Finger 2 |
| Chromosome | 2q14.2 |
| Protein Type | Transcription Factor |
| Function | encodes a 1586 amino acid zinc finger transcription factor that functions as the primary transcriptional activator of the Hedgehog (Hh) signaling pathway. |
| Primary Expression | the ventral neural tube floor plate, where it is essential for specification of ventral cell fates including dopaminergic progenitors of the midbrain |
| Amino Acids | 1586 aa |
| Exons | 13 |
| Pathways | Apoptosis, Hedgehog |
| Ensembl ID | ENSG00000074047 |
| GeneCards | GLI2 |
| Human Protein Atlas | GLI2 |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | IL6, LAMP1, MAP1LC3B, MTOR, PPARA, PSEN1 |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GLI2["GLI2"]
Colorectal_Cancer{"Colorectal Cancer"}
GLI2 -->|"activates"| Colorectal_Cancer
Cancer{"Cancer"}
GLI2 -->|"activates"| Cancer
Tumor{"Tumor"}
GLI2 -->|"activates"| Tumor
Apoptosis(["Apoptosis"])
GLI2 -->|"activates"| Apoptosis
Hedgehog(["Hedgehog"])
GLI2 -->|"activates"| Hedgehog
GLI1["GLI1"]
GLI1 -->|"activates"| GLI2
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"activates"| GLI2
BCL2["BCL2"]
BCL2 -->|"activates"| GLI2
CANCER["CANCER"]
CANCER -->|"activates"| GLI2
SMO["SMO"]
SMO -->|"activates"| GLI2
neurodegeneration["neurodegeneration"]
GLI2 -->|"implicated_in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Colorectal Cancer | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| IL6 | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| PPARA | activates | gene | 0.60 |
| PSEN1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| SYP | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Hedgehog | activates | pathway | 0.60 |
| LC3B | activates | gene | 0.60 |
| PS1 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||