gene 1,477 words KG: TTR 2026-03-24
kind:genesection:genesstate:published
Contents

TTR — Transthyretin

🧬 Gene Info
Gene SymbolTTR
Full NameTransthyretin
Chromosome18q12.1
FunctionUnder normal conditions, TTR functions as
Primary ExpressionLiver, Choroid plexus, Retinal pigment epithelium, Pancreas
Molecular Weight55 kDa
Amino Acids127 aa
UniProt IDP02766
NCBI Gene ID7276
Ensembl IDENSG00000118271
OMIM176300
GeneCardsTTR
Human Protein AtlasTTR
Associated DiseasesAls, Hereditary Polyneuropathies, Hereditary Polyneuropathy, Ms
InteractionsPPARG, ESR1, MMP2, SLC2A1, TAU, DEMENTIA
KG Connections63 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.43

Related Analyses (2)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
RELA (NF-κB p65)
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TTR therapeutic_target LGALS3
TTR therapeutic_target CTSD
TTR therapeutic_target GRB2
TTR therapeutic_target TLR4
TTR therapeutic_target NFE2L2
TTR therapeutic_target RPS6KA1
TTR therapeutic_target HIF1A
TTR therapeutic_target GRIN1
TTR therapeutic_target ADAM10
TTR interacts_with PPARG