gene 723 words KG: VAPB 2026-03-21
kind:genesection:genesstate:published
Contents

VAPB (VAMP-Associated Protein B)

🧬 Gene Info
Gene SymbolVAPB
Full NameVesicle-Associated Membrane Protein-Associated Protein B
AliasesVAMP-Associated Protein B
Chromosome20q13.33
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight33 kDa
Amino Acids243 aa
PathwaysImmune Response
UniProt IDO95295
NCBI Gene ID9217
Ensembl IDENSG00000124194
OMIM608627
GeneCardsVAPB
Human Protein AtlasVAPB
Protein NameVAP-B
Associated DiseasesAging, Als, Amyotrophic Lateral Sclerosis, Cardiovascular, Dementia, Ms
InteractionsVCP, NPC1, FUS, OPTN, UBQLN2, AND
KG Connections83 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Lysosomal Membrane Repair Enhancement
Score: 0.45

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

VAPB associated_with CHMP2B
VAPB associated_with TARDBP
VAPB associated_with SOD1
VAPB associated_with FUS
VAPB regulates TBK1
VAPB regulates STING
VAPB regulates OVERVIEW
VAPB therapeutic_target OVERVIEW
VAPB interacts_with neurodegeneration
VAPB associated_with VCP