gene

ATF6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

430Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATF6 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 303 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATF6
Full Name	Activating Transcription Factor 6
Chromosome	1q22.1
Function	is a Type II transmembrane protein that serves as a critical endoplasmic reticulum (ER) stress sensor and transcriptional activator.
Molecular Weight	90 kDa
Pathways	Akt, Autophagy, Lipid Metabolism, Mapk, Mtor
UniProt ID	[Q09470](https://www.uniprot.org/uniprot/Q09470)
Ensembl ID	ENSG00000118260
OMIM	604436
GeneCards	ATF6
Human Protein Atlas	ATF6
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/Compounds	rapamycin
Interactions	DDIT3, NBR1, HSP70, TFE3, MAP1LC3A, MLKL
KG Connections	427 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATF6["ATF6"] -->|"interacts"| Cancer["Cancer"]
    ATF6["ATF6"] -->|"interacts"| Als["Als"]
    ATF6["ATF6"] -->|"interacts"| Ms["Ms"]
    ATF6["ATF6"] -->|"regulates"| Fibrosis["Fibrosis"]
    ATF6["ATF6"] -->|"activates"| Ms_1["Ms"]
    ATF6["ATF6"] -->|"activates"| Als_2["Als"]
    OPTN["OPTN"] -->|"interacts"| ATF6["ATF6"]
    CASP3["CASP3"] -->|"regulates"| ATF6["ATF6"]
    AKT1["AKT1"] -->|"regulates"| ATF6["ATF6"]
    CALCOCO2["CALCOCO2"] -->|"regulates"| ATF6["ATF6"]
    style ATF6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (290)

Target	Relation	Type	Str
Als	activates	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Mtor	activates	pathway	0.70
CANCER	activates	gene	0.70
Arthritis	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Ms	activates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Autoimmune	activates	disease	0.65
Cardiac	activates	disease	0.65
Hepatitis	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Huntington	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
ALS	activates	disease	0.65
Osteoarthritis	activates	disease	0.65
Parkinson	associated_with	disease	0.65

Incoming (140)

Source	Relation	Type	Str
OPTN	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CGAS	regulates	gene	0.60
CFTR	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	regulates	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	regulates	gene	0.60
HSPA5	activates	gene	0.60
ERN1	activates	gene	0.60
EIF2AK3	activates	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
ATF4	activates	gene	0.60
DDIT3	activates	gene	0.60
TREM2	activates	gene	0.60
BNIP3	regulates	gene	0.60
NR3C1	activates	gene	0.60
NOX4	activates	gene	0.60
P62	activates	gene	0.60
AKT1	inhibits	gene	0.60
RAB7A	regulates	gene	0.60
YAP1	activates	gene	0.60
ERK1	activates	gene	0.60
MFN2	activates	gene	0.60
CD4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATF6

Understanding Entity Pages

Summary

Wiki Pages (21)

ATF6 - Activating Transcription Factor 6

cbs-psp-daily-action-plan

APOC4 — Apolipoprotein C-IV

psp-tauopathy

Copper Dyshomeostasis in Neurodegeneration

RPL30 — Ribosomal Protein L30 in Neurodegeneration

PEN2 Gene

RNA Metabolism Dysregulation in Alzheimer's Disease

GBA1→GCase→Lysosome→PD Causal Chain

Synuclein Pathway in Parkinson's Disease

NF-kB Signaling Pathway in Neurodegeneration

er-stress-neurodegeneration

Unfolded Protein Response (UPR)

Endoplasmic Reticulum Stress Comparison Across Neurodegenerative Diseases

GLI1 — GLI Family Zinc Finger 1

VPS35 Retromer Dysfunction Parkinson's Disease Causal Chain

Mechanisms Dashboard

ALS RNA Metabolism and Proteostasis Failure

Apoptosis Pathway in Neurodegeneration