gene

ATF6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

429Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ATF6 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 303 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATF6
Full Name	Activating Transcription Factor 6
Chromosome	1q22.1
Function	is a Type II transmembrane protein that serves as a critical endoplasmic reticulum (ER) stress sensor and transcriptional activator.
Molecular Weight	90 kDa
Pathways	Akt, Autophagy, Lipid Metabolism, Mapk, Mtor
UniProt ID	[Q09470](https://www.uniprot.org/uniprot/Q09470)
Ensembl ID	ENSG00000118260
OMIM	604436
GeneCards	ATF6
Human Protein Atlas	ATF6
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/Compounds	rapamycin
Interactions	AKT, AKT1, AKT1S1, ALZHEIMER'S DISEASE, AMPK, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections	426 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATF6["ATF6"] -->|"interacts"| Cancer["Cancer"]
    ATF6["ATF6"] -->|"interacts"| Als["Als"]
    ATF6["ATF6"] -->|"interacts"| Ms["Ms"]
    ATF6["ATF6"] -->|"regulates"| Fibrosis["Fibrosis"]
    ATF6["ATF6"] -->|"activates"| Ms_1["Ms"]
    ATF6["ATF6"] -->|"activates"| Als_2["Als"]
    OPTN["OPTN"] -->|"interacts"| ATF6["ATF6"]
    CASP3["CASP3"] -->|"regulates"| ATF6["ATF6"]
    AKT1["AKT1"] -->|"regulates"| ATF6["ATF6"]
    CALCOCO2["CALCOCO2"] -->|"regulates"| ATF6["ATF6"]
    style ATF6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (289)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATF6	data_in	dataset_row	0.00
Cancer	activates	disease	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
Mtor	activates	pathway	0.70
Myelin integrity	protective_against	process	0.70
CANCER	activates	gene	0.70
ALS	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Osteoarthritis	activates	disease	0.65
Als	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Cardiac	activates	disease	0.65
ALS	interacts_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Autoimmune	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Hepatitis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Autoimmune	activates	disease	0.65
Ms	expressed_in	disease	0.65
Huntington	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	regulates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Arthritis	activates	disease	0.65
Tumor	regulates	disease	0.65

Incoming (140)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATF6	data_in	dataset_row	0.00
CAMK2D	upregulates	gene	0.80
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CGAS	regulates	gene	0.60
CFTR	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	regulates	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	regulates	gene	0.60
HSPA5	activates	gene	0.60
ERN1	activates	gene	0.60
EIF2AK3	activates	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
RICTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
APC	regulates	gene	0.60
DEPTOR	interacts_with	gene	0.60
NLRP3	regulates	gene	0.60
HMGB1	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
TP53	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What specific gene expression signatures in aging mouse white matter predict hum

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate initiated investigation into white matter aging and myelin changes bu

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning ATF6 in their description or question text

No additional research found