gene 2,168 words KG: WDR81 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

WDR81 — WD Repeat Domain 81

🧬 Gene Info
Gene SymbolWDR81
Full NameWD Repeat Domain 81
Chromosome17p13.1
Functionencodes a protein containing multiple WD repeat domains, which form beta-propeller structures that mediate protein-protein interactions.
Primary Expressionthe brain, particularly in the cerebellum and cerebral cortex, where it plays crucial roles in neuronal development, synaptic function, and autophagy
Molecular Weight270 kDa
Amino Acids443 aa
Exons28
PathwaysMAPK, PI3K
UniProt ID[Q9H6X7](https://www.uniprot.org/uniprot/Q9H6X7)
Ensembl IDENSG00000167792
OMIM614518
GeneCardsWDR81
Human Protein AtlasWDR81
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsGNPTG, GNAI3, AMPD2, CLCN7, JIP4, TMEM55B
KG Connections28 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Low Complexity Domain Cross-Linking Inhibition
Score: 0.42

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Wilson Disease Neurodegeneration: Mechanism and Therapeutic
clinical · proposed · Score: 0.40

See Also (15)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: expressed_in
TBK1-Mediated Neuroinflammation Hypothesis — Autophagy
hypothesis · KG edge: expressed_in
RIPK2 (Receptor-Interacting Serine/Threonine-Protein Ki
gene · KG edge: expressed_in
NOD2 Gene
gene · KG edge: expressed_in
MAVS Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

WDR81 activates GNPTG
WDR81 expressed_in GNAI2
WDR81 expressed_in NOD2
WDR81 expressed_in GNAS
WDR81 activates GNAI3
WDR81 expressed_in Cardiovascular
WDR81 expressed_in Autophagy
WDR81 expressed_in Wnt
WDR81 expressed_in Akt
WDR81 participates_in PI3K-AKT-mTOR signaling