gene 898 words KG: USP7 2026-03-24
kind:genesection:genesstate:published
Contents

USP7 Gene

🧬 Gene Info
Gene SymbolUSP7
Full NameUbiquitin-Specific Peptidase 7
AliasesHAUSP (Herpesvirus-Associated USP)
Chromosome16p13.2
Protein TypeEnzyme
Functionencodes a deubiquitinating enzyme (DUB) that removes ubiquitin from target proteins, regulating their stability and function.
Molecular Weight128 kDa
Amino Acids102 aa
PathwaysNF-κB, Wnt signaling
UniProt IDQ93009
NCBI Gene ID7874
Ensembl IDENSG00000187555
OMIM602519
GeneCardsUSP7
Human Protein AtlasUSP7
Associated DiseasesALS, Cancer, Huntington's disease, glioblastoma
Known Drugs/CompoundsH2O2
InteractionsHNRNPA1, ALOX15, AMBRA1, NRF2, UBIQUITIN, OXIDATIVE STRESS
KG Connections159 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: associated_with
CFTR Gene
gene · KG edge: associated_with
CD4 Gene
gene · KG edge: activates
CAV1
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

USP7 inhibits HNRNPA1
USP7 inhibits ALOX15
USP7 activates AMBRA1
USP7 activates NRF2
USP7 regulates UBIQUITIN
USP7 inhibits UBIQUITIN
USP7 regulates AKT
USP7 regulates MTOR
USP7 stabilizes MLKL
USP7 stabilizes UBIQUITIN