concept

LOXL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOXL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

48Outgoing

23Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LOXL1
Key Genes/Proteins	LOXL3, AND
Related Diseases	Glioma, Cancer Prognosis, Ms, Cancer, Tumor
Related Pathways	Therapeutic Target

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LOXL1["LOXL1"]
    LOXL1 -->|"involved_in"| Cancer_Progression["Cancer Progression"]
    LOXL1 -.biomarker for.-> Cancer_Prognosis["Cancer Prognosis"]
    LOXL1 -->|"correlates_with"| Tumor_Progression["Tumor Progression"]
    LOXL1 -.biomarker for.-> Cancer["Cancer"]
    LOXL1 -->|"participates in"| Extracellular_Matrix["Extracellular Matrix"]
    LOXL1 -->|"target for"| Ms["Ms"]
    LOXL1 -->|"target for"| Tumor["Tumor"]
    GENES["GENES"] -->|"target for"| LOXL1
    LOXL3["LOXL3"] -->|"target for"| LOXL1
    CANCER["CANCER"] -->|"regulates"| LOXL1
    LOX["LOX"] -->|"regulates"| LOXL1
    LOXL1_4["LOXL1-4"] -->|"regulates"| LOXL1
    LOXL2["LOXL2"] -->|"expressed in"| LOXL1
    RNA["RNA"] -->|"expressed in"| LOXL1

Outgoing (48)

Target	Relation	Type	Str
Cancer Progression	involved_in	process	0.95
Cancer Progression	promotes	process	0.95
Glioma	associated_with	disease	0.92
Cancer Prognosis	biomarker_for	phenotype	0.90
Tumor Progression	correlates_with	process	0.90
tumor progression	promotes	process	0.80
Therapeutic Target	targets	mechanism	0.75
Ms	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	implicated_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	regulates	disease	0.65
AND	regulates	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
LOXL2	therapeutic_target	gene	0.60
LOXL1-4	regulates	gene	0.60
LR.LOXL3	implicated_in	gene	0.60
AND	implicated_in	gene	0.60
LOX/LOXL1-4	associated_with	gene	0.60
LOXL1-4	associated_with	gene	0.60
Lipid Metabolism	implicated_in	pathway	0.60
Immune Response	implicated_in	pathway	0.60
Immune Response	regulates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
CANCER	regulates	gene	0.60
LOXL3	expressed_in	gene	0.60
LOXL2	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
LOX	regulates	gene	0.60
GENES	expressed_in	gene	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
LR.LOXL3	regulates	gene	0.60
LOXL3	stabilizes	gene	0.60
LOXL1-4	stabilizes	gene	0.60
LOX	stabilizes	gene	0.60
LOXL3	associated_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
LOXL3	co_expressed_with	gene	0.60
glioblastoma	co_expressed_with	disease	0.60
MYOC	activates	gene	0.60
OPTN	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
T Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
LOXL2	associated_with	gene	0.55
LOXL4	associated_with	gene	0.55
LOXL2	targets	gene	0.55

Incoming (23)

Source	Relation	Type	Str
LOXL3	interacts_with	gene	0.75
GENES	therapeutic_target	gene	0.60
LOXL3	therapeutic_target	gene	0.60
CANCER	regulates	gene	0.60
LOX	regulates	gene	0.60
LOXL3	associated_with	gene	0.60
LOX	associated_with	gene	0.60
LOXL1-4	regulates	gene	0.60
GENES	expressed_in	gene	0.60
LOXL2	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	regulates	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
LOXL3	expressed_in	gene	0.60
LOXL1-4	stabilizes	gene	0.60
LOX	stabilizes	gene	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
LOXL3	stabilizes	gene	0.60
LR.LOXL3	regulates	gene	0.60
LOX	expressed_in	gene	0.60
GBM	co_expressed_with	gene	0.60
LOX	co_expressed_with	gene	0.60
LOX	targets	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LOXL1

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Sulforaphane and Nrf2 Activation for Neuroprotection

DNA Damage Response in Corticobasal Syndrome

ASC (PYCARD)

RAN Gene

Targeted Protein Degradation (PROTACs)

Tau-Targeted Therapeutics

Therapeutic Antibody Comparison Matrix

NRF2 Gene

nadph-oxidase-inhibitors

Tau Aggregation Inhibitors

NRF2 — Nuclear Factor Erythroid 2-Related Factor 2

Prostaglandin and Eicosanoid Signaling in CBS/PSP

Kinase and Phosphatase Therapeutic Target Matrix

Section 193 Advanced Integrated Cell Stress Response Therapy in CBS/PSP

ACE Protein

nrf2-activators-parkinsons-disease