Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LOXL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LOXL2 |
| Related Diseases | Glioma, Prostate Cancer, Ms, Cancer, Tumor |
graph TD
LOXL2["LOXL2"]
LOXL2 -->|"involved_in"| Cancer_Progression["Cancer Progression"]
LOXL2 -->|"target for"| Ms["Ms"]
LOXL2 -->|"target for"| Cancer["Cancer"]
LOXL2 -->|"target for"| Tumor["Tumor"]
GENES["GENES"] -->|"target for"| LOXL2
LOXL3["LOXL3"] -->|"target for"| LOXL2
CANCER["CANCER"] -->|"target for"| LOXL2
LOX["LOX"] -->|"activates"| LOXL2
LOXL1["LOXL1"] -->|"target for"| LOXL2
AND["AND"] -->|"activates"| LOXL2
LOX_LOXL1_4["LOX/LOXL1-4"] -->|"target for"| LOXL2| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer Progression | involved_in | process | 0.95 |
| Cancer Progression | promotes | process | 0.95 |
| Glioma | associated_with | disease | 0.92 |
| tumor progression | promotes | process | 0.80 |
| Prostate Cancer | associated_with | disease | 0.80 |
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Glioblastoma | activates | disease | 0.65 |
| Glioblastoma | therapeutic_target | disease | 0.65 |
| Glioblastoma | encodes | disease | 0.65 |
| LOXL1-4 | therapeutic_target | gene | 0.60 |
| Complement | regulates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| HSPG2 | activates | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| LOX/LOXL1-4 | expressed_in | gene | 0.60 |
| LOXL3 | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| LOXL1 | expressed_in | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| Blood-Brain Barrier | activates | pathway | 0.60 |
| Cerebrovascular | activates | pathway | 0.60 |
| T Cell | regulates | cell_type | 0.60 |
| GLIOBLASTOMA | therapeutic_target | gene | 0.60 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.60 |
| Endothelial | therapeutic_target | cell_type | 0.60 |
| Neuron | therapeutic_target | cell_type | 0.60 |
| LOX | activates | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| GBM | activates | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Laminin | activates | protein | 0.60 |
| Blood-Brain Barrier | encodes | pathway | 0.60 |
| Neuron | encodes | cell_type | 0.60 |
| Endothelial | encodes | cell_type | 0.60 |
| Collagen | activates | protein | 0.60 |
| Raf | activates | protein | 0.60 |
| Rb | therapeutic_target | protein | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| glioblastoma | activates | disease | 0.60 |
| STAT3 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GENES | therapeutic_target | gene | 0.60 |
| LOXL3 | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| LOX | activates | gene | 0.60 |
| LOXL1 | therapeutic_target | gene | 0.60 |
| AND | activates | gene | 0.60 |
| LOX/LOXL1-4 | therapeutic_target | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| HSPG2 | activates | gene | 0.60 |
| LOXL1-4 | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| GBM | activates | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| LOXL1 | expressed_in | gene | 0.60 |
| LOX/LOXL1-4 | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| LOXL3 | expressed_in | gene | 0.60 |
| RNA | encodes | gene | 0.60 |
| GLIOBLASTOMA | encodes | gene | 0.60 |
| LOX | associated_with | gene | 0.55 |
| LOXL1 | associated_with | gene | 0.55 |
| LOX | targets | gene | 0.55 |
| LOXL1 | targets | gene | 0.55 |
| HIF | activates | gene | 0.55 |
| APP | associated_with | gene | 0.55 |
| LOX | inhibits | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||