mechanism 1,457 words KG: PSP 2026-04-01
mechanismmechanismspublished
Contents

Eye Movement Abnormalities in Corticobasal Syndrome

Mechanism Info
NamePSP
SummaryComprehensive analysis of oculomotor dysfunction in CBS, including saccadic disorders, pursuit deficits, and diagnostic value
Key Genes/ProteinsALZHEIMER'S DISEASE, SV2A, STX6, MOBP
Related DiseasesAlzheimer, Als, Alzheimer's disease, tauopathy, frontotemporal dementia
Related Pathwaysunfolded protein response, oxidative stress response

Knowledge Graph

Related Hypotheses (28)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Smartphone-Detected Motor Variability Correction
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

PSP downregulates SV2A
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
PSP activates VPS29
PSP activates MAPT