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mechanism 3,582 words KG: lysosomal dysfunction
Contents

Lysosomal Dysfunction in Neurodegeneration

⚙ Mechanism Info
Namelysosomal dysfunction
Key Genes/Proteinsamyloid-beta, AMYOTROPHIC LATERAL SCLEROSIS, APOE4, AR, C3, C9orf72
Related Diseasesalpha-synuclein aggregation, ALS, Alzheimer's disease, amyotrophic lateral sclerosis
Related Pathwaysautophagy pathway, Aβ accumulation
Linked Hypotheses2 hypotheses

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Wikipedia

Related Hypotheses (153)

APOE-Dependent Autophagy Restoration
Score: 0.89Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74APOE Isoform Conversion Therapy
Score: 0.72Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
← Prevpg 8/8

Related Analyses (30)

Does TFEB dysfunction cause neurodegeneration or represent a
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40DLB Treatment Response Biomarkers — Predicting Cholinesteras
clinical · proposed · Score: 0.40

See Also (15)

Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesBEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 139 hypothesesBeta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypotheses

Knowledge Graph (12 edges)

TREM2 p.Q33X mutation causes lysosomal dysfunction
lysosomal dysfunction associated_with carcinoma
TDP-43 activates lysosomal dysfunction
GRN causes lysosomal dysfunction
MAPT causes lysosomal dysfunction
C9orf72 causes lysosomal dysfunction
TBK1 prevents lysosomal dysfunction
C3 activates lysosomal dysfunction
RAC1 activates lysosomal dysfunction
TFEB activates lysosomal dysfunction

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