| Gene Symbol | PIN1 |
| Full Name | Peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1 |
| Protein Type | Isomerase |
| Function | PIN1 is a unique peptidyl-prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of peptide bonds preceding phosphorylated serine or threonine residues. |
| Amino Acids | 163 aa |
| Pathways | MAPK, PI3K, Wnt, NF-κB |
| Ensembl ID | ENSG00000100429 |
| GeneCards | PIN1 |
| Human Protein Atlas | PIN1 |
| WW Domain | N-terminal domain that recognizes phosphorylated serine/threonine-proline motifs |
| PPIase Domain | C-terminal catalytic domain that catalyzes cis-trans isomerization |
| Substrate Specificity | Highly specific for pSer/Thr-Pro motifs, unique among PPIases |
| Beneficial Function | Catalyzes isomerization of phosphorylated tau, promoting proper tau function |
| Pathogenic Dysfunction | In AD brain, PIN1 activity is reduced, leading to tau hyperphosphorylation and neurofibrillary tangle formation |
| Therapeutic Target | PIN1 activators are being explored as potential AD therapeutics |
| Associated Diseases | AD brain neurodegeneration, Als, Alzheimer, Alzheimer's disease, Cancer, Dementia |
| Interactions | AD, AND, ANXA2, AΒ, CANCER, cis-pS199 Tau conformer |
| KG Connections | 180 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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