protein 1,140 words KG: BIP 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

BiP - Binding Immunoglobulin Protein (GRP78)

🔬 Protein Info
Gene SymbolBIP
Full NameBiP - Binding Immunoglobulin (GRP78)
AliasesHSPA5/GRP78
Protein TypeProtein
FunctionDe Novo Folding: Binds nascent polypeptide chains as they enter the ER via the Sec61 translocon
Molecular Weight78 kDa
Amino Acids654 aa
PathwaysAutophagy, Mapk, Mtor, Pi3K/Akt, Unfolded Protein Response
UniProt IDP11021
GeneCardsBIP
Human Protein AtlasBIP
Associated DiseasesTumor
InteractionsJNK1, JNK2, CHOP, JUN, P38, TSC2
KG Connections181 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
BDNF Gene
gene · KG edge: activates
BAX Gene
gene · KG edge: activates
ATF6 - Activating Transcription Factor 6
gene · KG edge: activates
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BIP activates JNK1
BIP activates JNK2
BIP activates CHOP
BIP activates JUN
BIP activates P38
BIP activates TSC2
BIP activates EIF2AK3
BIP activates GSK3B
BIP activates ERN1
BIP activates HSPA5