protein 833 words KG: LRP2 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LRP2 Protein (Megalin)

🔬 Protein Info
Gene SymbolLRP2
Full NameLRP2 (Megalin)
AliasesPage for LRP2 Protein, Megalin
Chromosome2q31.1
Protein TypeProtein
Functionis a giant multiligand endocytic receptor of the LDL receptor family with high physiological relevance at epithelial interfaces, including the choroid plexus and brain barriers.
Molecular Weight600 kDa
Amino Acids630 aa
Exons79
PathwaysAngiogenesis, Apoptosis, Autophagy, Lipid Metabolism, Mtor
UniProt IDSearch UniProt
GeneCardsLRP2
Human Protein AtlasLRP2
Associated DiseasesAD, ADH, ALS, AMI, Aging
Known Drugs/Compoundsrapamycin
InteractionsEIF4EBP1, LAMP1, MCOLN1, SOX9, TFEB, ULK1
KG Connections267 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (19)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
CAT — Catalase
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: regulates

Knowledge Graph (12 edges)

LRP2 activates MAP1LC3B
LRP2 activates MTOR
LRP2 activates MYC
LRP2 activates PIK3C3
LRP2 activates PPARA
LRP2 activates PPARG
LRP2 activates PPARGC1A
LRP2 activates RAB7A
LRP2 activates RPS6
LRP2 activates RPS6KB1