protein 833 words KG: LRP2
Contents

LRP2 Protein (Megalin)

🔬 Protein Info
Gene SymbolLRP2
Full NameLRP2 (Megalin)
AliasesPage for LRP2 Protein, Megalin
Chromosome2q31.1
Protein TypeProtein
Functionis a giant multiligand endocytic receptor of the LDL receptor family with high physiological relevance at epithelial interfaces, including the choroid plexus and brain barriers.
Molecular Weight600 kDa
Amino Acids630 aa
Exons79
PathwaysAngiogenesis, Apoptosis, Autophagy, Lipid Metabolism, Mtor
UniProt IDSearch UniProt
GeneCardsLRP2
Human Protein AtlasLRP2
Associated DiseasesAD, ADH, Aging, Als, AMI
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AND, APOPTOSIS, ATG, ATP, CANCER
KG Connections260 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (19)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Astrocytes
entity · KG edge: regulates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates

Knowledge Graph (12 edges)

ACTB regulates LRP2
PPARA regulates LRP2
CAT regulates LRP2
SQSTM1 regulates LRP2
RPS6KB1 regulates LRP2
RAB7A regulates LRP2
SREBF1 regulates LRP2
EIF4EBP1 regulates LRP2
CTSD regulates LRP2
PPARGC1A regulates LRP2

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