protein 570 words KG: MFN2 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Mitofusin 2 (MFN2)

🔬 Protein Info
Gene SymbolMFN2
AliasesMitofusin 2
Chromosome1p36.22
FunctionTrans-tethering: HR2 domains form antiparallel complexes between adjacent mitochondria
Subcellular Localizationthe outer mitochondrial membrane that functions as a critical regulator of mitochondrial dynamics and inter-organellar c
Molecular Weight84 kDa
Amino Acids757 aa
Exons17
PathwaysNF-κB, AMPK
GeneCardsMFN2
Human Protein AtlasMFN2
Associated DiseasesAls, CHARCOT-MARIE-TOOTH, Charcot-Marie-Tooth Type 2A, Fibrosis, Hereditary Polyneuropathy, Huntington
Known Drugs/Compounds8015-P2, Piperine
InteractionsGSDMD, RIPK1, RAB7A, CAT, CCR5, APP
KG Connections729 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (26)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (5)

Alzheimer Indonesia
institution · KG edge: inhibits
AKT1 Gene
gene · KG edge: activates
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

MFN2 regulates MTOR
MFN2 activates GSDMD
MFN2 activates RIPK1
MFN2 activates RAB7A
MFN2 activates CAT
MFN2 regulates OPA1
MFN2 interacts_with CCR5
MFN2 interacts_with APP
MFN2 associated_with MBP
MFN2 expressed_in PSD95