| Gene Symbol | MTOR |
| Full Name | Mechanistic Target of Rapamycin |
| Chromosome | 1p36.22 |
| Protein Family | PI3K-related kinase family |
| Protein Type | Serine/Threonine Kinase |
| Target Class | Kinase |
| Function | mTOR is a central kinase integrating nutritional, growth factor, and energy signals |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: APOE-Dependent Autophagy Restoration |
| Subcellular Localization | Cytosol, Lysosomes |
| Druggability | High (0.50) |
| Clinical Stage | Approved |
| Molecular Weight | ~289 kDa (2549 amino acids) |
| Amino Acids | 2549 amino acids |
| Pathways | autophagy-lysosome pathway, lysosomal biogenesis |
| UniProt ID | P42345 |
| NCBI Gene ID | 2475 |
| Ensembl ID | ENSG00000164362 |
| OMIM | 601231 |
| GeneCards | MTOR |
| Human Protein Atlas | MTOR |
| Associated Diseases | AD, ADH, ALS, ALZHEIMER'S DISEASE, AMI, ARM |
| Known Drugs/Compounds | lysosomal cholesterol, LENVATINIB, Zhenwu Decoction, RAPAMYCIN, NMN, QUERCETIN |
| Interactions | ABCG1, SQSTM1, ABCA1, APOE, LOX, PIK3C3 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | APOE-Dependent Autophagy Restoration |
| KG Connections | 5929 knowledge graph edges |
| Databases | GeneCardsHPASTRING |